Hybrid giant lipid vesicles incorporating a PMMA-based copolymer

In recent years, there has been a growing interest in the formation of copolymer-lipid hybrid self-assemblies, which allow combining and improving main features pure lipid-based copolymer-based systems known for their potential applications biomedical field. As most common method used to obtain giant vesicles is electroformation, so far low Tg polymers flexibility at room temperature. Copolymers have synthesized by modified version ATRP, namely Activators ReGenerated Electron Transfer ATRP characterized NMR DSC. Giant obtained using electroformation droplet transfer method. Confocal fluorescence microscopy was image vesicles. Electroformation enabled narrow range compositions (15 mol% maximum copolymer content). This could be extended use method, obtaining incorporating methacrylate-based polymer wide compositions. Proof composition labeled lipids copolymers. work describes first time, best our knowledge, polymer/lipid formed with such content polymethylmethacrylate copolymer, glass temperature above shows that structures, more complex than ones mostly employed, can possibly included will give easier access functionalized stimuli-responsive exhibiting tunable permeability, these being relevant biological technological applications.